Development of control systems for space shuttle vehicles, volume 1

Control of winged two-stage space shuttle vehicles was investigated. Control requirements were determined and systems capable of meeting these requirements were synthesized. Control requirements unique to shuttles were identified. It is shown that these requirements can be satisfied by conventional control logics. Linear gain schedule controllers predominate. Actuator saturations require nonlinear compensation in some of the control systems

The Most Luminous z~9-10 Galaxy Candidates yet Found: The Luminosity Function, Cosmic Star-Formation Rate, and the First Mass Density Estimate at 500 Myr

[abridged] We present the discovery of four surprisingly bright (H_160 ~ 26 - 27 mag AB) galaxy candidates at z~9-10 in the complete HST CANDELS WFC3/IR GOODS-N imaging data, doubling the number of z~10 galaxy candidates that are known, just ~500 Myr after the Big Bang. Two similarly bright sources are also detected in a systematic re-analysis of the GOODS-S data set. Three of the four galaxies in GOODS-N are significantly detected at 4.5-6.2sigma in the very deep Spitzer/IRAC 4.5 micron data, as is one of the GOODS-S candidates. Furthermore, the brightest of our candidates (at z=10.2+-0.4) is robustly detected also at 3.6 micron (6.9sigma), revealing a flat UV spectral energy distribution with a slope beta=-2.0+-0.2, consistent with demonstrated trends with luminosity at high redshift. The abundance of such luminous candidates suggests that the luminosity function evolves more significantly in phi_* than in L_* at z>~8 with a higher number density of bright sources than previously expected. Despite the discovery of these luminous candidates, the cosmic star formation rate density for galaxies with SFR >0.7 M_sun/yr shows an order-of-magnitude increase in only 170 Myr from z ~ 10 to z ~ 8, consistent with previous results. Based on the IRAC detections, we derive galaxy stellar masses at z~10, finding that these luminous objects are typically 10^9 M_sun. The cosmic stellar mass density at z~10 is log10 rho_* = 4.7^+0.5_-0.8 M_sun Mpc^-3 for galaxies brighter than M_UV~-18. The remarkable brightness, and hence luminosity, of these z~9-10 candidates highlights the opportunity for deep spectroscopy to determine their redshift and nature, demonstrates the value of additional search fields covering a wider area to understand star-formation in the very early universe, and highlights the opportunities for JWST to map the buildup of galaxies at redshifts much earlier than z~10.Comment: 20 pages, 12 figures, changed to match resubmitted version to Ap

Gamma ray monitoring of a AGN and galactic black hole candidates by the Compton Gamma Ray Observatory

The Compton Gamma-Ray Observatory's Burst and Transient Source Experiment (BATSE) has a powerful capability to provide nearly uninterrupted monitoring in the 25 keV-10 MeV range of both active galactic nuclei (AGN) and galactic black hole candidates (GBHC) such as Cygnus X-1, using the occultation of cosmic sources by the Earth. Since the Crab is detected by the BATSE Large Area Detectors with roughly 25(sigma) significance in the 15-125 keV range in a single rise or set, a variation by a factor of two of a source having one-tenth the strength of Cygnus X-1 should be detectable within a day. Methods of modeling the background are discussed which will increase the accuracy, sensitivity, and reliability of the results beyond those obtainable from a linear background fit with a single rise or set discontinuity

Acquired heart block: A possible complication of patent ductus arteriosus in a preterm infant

A large patent ductus arteriosus (PDA) is a frequently encountered clinical problem in extremely low birth weight (ELBW) infants. It leads to an increased pulmonary blood flow and in a decreased or reversed diastolic flow in the systemic circulation, resulting in complications. Here we report a possible complication of PDA not previously published. On day 8 of life, a male ELBW infant (birth weight 650 g) born at a gestational age of 23 weeks and 3 days developed an atrioventricular block (AV block). The heart rate dropped from 168/min to 90/min, and the ECG showed a Wenckebach second-degree AV block and intraventricular conduction disturbances. Echocardiography demonstrated a PDA with a large left-to-right shunt and large left atrium and left ventricle with high contractility. Within several minutes after surgical closure of the PDA, the heart rate increased, and after 30 min the AV block had improved to a 1: 1 conduction ratio. Echocardiography after 2 h revealed a significant decrease of the left ventricular and atrial dimensions. Within 12 h, the AV block completely reversed together with the intraventricular conduction disturbances. We suggest that PDA with a large left-to-right shunt and left ventricular volume overload may lead to an AV block in an ELBW infant. Surgical closure of the PDA may be indicated. Copyright (C) 2007 S. Karger AG, Basel

SrfB, a member of the Serum Response factor family of transcription factors, regulates starvation response and early development in Dictyostelium

The Serum Response Factor (SRF) is an important regulator of cell proliferation and differentiation. Dictyostelium discoideum srfB gene codes for an SRF homologue and is expressed in vegetative cells and during development under the control of three alternative promoters, which show different cell-type specific patterns of expression. The two more proximal promoters directed gene transcription in prestalk AB, stalk and lower-cup cells. The generation of a strain where the srfB gene has been interrupted (srfB(−)) has shown that this gene is required for regulation of actin–cytoskeleton-related functions, such as cytokinesis and macropinocytosis. The mutant failed to develop well in suspension, but could be rescued by cAMP pulsing, suggesting a defect in cAMP signaling. srfB(−) cells showed impaired chemotaxis to cAMP and defective lateral pseudopodium inhibition. Nevertheless, srfB(−) cells aggregated on agar plates and nitrocellulose filters 2 h earlier than wild type cells, and completed development, showing an increased tendency to form slug structures. Analysis of wild type and srfB(−) strains detected significant differences in the regulation of gene expression upon starvation. Genes coding for lysosomal and ribosomal proteins, developmentally-regulated genes, and some genes coding for proteins involved in cytoskeleton regulation were deregulated during the first stages of development

Visual activism and social justice: using visual methods to make young people’s complex lives visible across ‘public’ and ‘private’ spaces

Much critical social justice research, including work employing visual methods, focuses on young people’s use of public spaces leaving domestic spaces relatively unexplored. Such research tacitly maintains modernist notions of the public/private distinction in which the private sphere is considered less relevant to concerns of social justice. However, UK crime and social justice policy has increasingly intervened in the home lives of the poorest British families. Further, such policies have been legitimated by drawing on (or not contesting) media imagery that constructs these family lives almost entirely negatively, obscuring their complexity. Drawing on childhood studies research, and a project that employed visual methods to explore belonging among young people in foster, kinship or residential care, this paper examines participants’ often fragile efforts to find or forge places in which they could feel at ‘home’ and imagine a future. In so doing, it invites visual activists to reconsider their understanding of public and private spaces in order to contest prevalent unsympathetic policy representations of poorer young people’s lives, to focus greater attention on their need for support, and to extend imaginations of their futures

New Limits to the Infrared Background: Bounds on Radiative Neutrino Decay and on Contributions of Very Massive Objects to the Dark Matter Problem

From considering the effect of γ-γ interactions on recently observed TeV gamma-ray spectra, improved limits are set to the density of extragalactic infrared photons which are robust and essentially model independent. The resulting limits are more than an order of magnitude more restrictive than direct observations in the 0.025–0.3 eV regime. These limits are used to improve constraints on radiative neutrino decay in the mass range above 0.05 eV and to rule out very massive objects as providing the dark matter needed to explain galaxy rotation curves. Lower bounds on the maximum distance which TeV gamma rays may probe are also derived